FIRST TRIMESTER HUMAN UMBILICAL CORD PERIVASCULAR CELLS (HUCPVC) MODULATE THE KYNURENINE PATHWAY AND GLUTAMATE NEUROTRANSMISSION IN AN LPS-INDUCED MOUSE MODEL OF NEUROINFLAMMATION

First trimester human umbilical cord perivascular cells (HUCPVC) modulate the kynurenine pathway and glutamate neurotransmission in an LPS-induced mouse model of neuroinflammation

Abstract Background The Kynurenine Pathway (KP) of tryptophan degradation and glutamate toxicity is implicated in several neurological disorders, including depression.The therapeutic potential of bar drain board mesenchymal stromal cells (MSC), owing to their well documented phagocytosis-driven mechanism of immunomodulation and neuroprotection, has

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Time from Symptom Onset to Diagnosis and Treatment among Haematological Malignancies: Influencing Factors and Associated Negative Outcomes

Background and objectives: Diagnostic delay causes unfavorable outcomes among cancer patients.It has been widely analyzed in solid tumors.However, data regarding hematological malignancies diagnostic delay are scarce.We aimed to evaluate diagnostic intervals, their influencing factors, and the negative effect on clinical outcomes among multiple mye

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Higgsino dark matter in a non-standard history of the universe

A light higgsino is strongly favored by the naturalness, while as a dark matter candidate it is usually under-abundant.We echofix spring reverb consider the higgsino production in a non-standard history of the universe, caused by a scalar field with an initially displaced vacuum.We find that given a proper reheating temperature induced by the scala

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